Clinical and Experimental Studies on Antibiotic-associated Colitis

Clostridium Difficile infection and Antibiotic –Associated Colitis

Hospitalized patients receiving β lactam antibiotics develop diarrhea and higher rates reported in those receiving clindamycin. Clostridiumdifficile is recognized as a cause of antibiotic associated diarrhea, colitis and pseudomembranous colitis. Contributory factors include: advance age, severity of underlying illness.C.difficile has the ability to temporarily colonize newborn humans and calve...

Antibiotic-associated hemorrhagic colitis with ischemic change.

A 67-year-old woman presented with abdominal pain and hematochezia. She had never used non-steroidal anti-inflammatory drugs, but had been started on amoxicillin, clarithromycin, and lansoprazole 3 days earlier as Helicobacter pylori eradication therapy. On admission, white blood cell count was 21600/μL and C-reactive protein level was 2.8mg/dL. Computed tomography showed thickening of the inte...

Roentgenographic features in antibiotic-associated pseudomembranous colitis.

CASE PRESENTATIONS Case 1 . A 62-year-old woman with diabetes was admitted because of an infected toe. Physical examination was normal except for an ulceration of the left 4th toe. Routine laboratory studies revealed only elevated blood sugar and moderate ketonuria. A roentgenogram of the toe revealed osteomyelitis. The infection improved with clindamycin therapy (300 mg IV, t:d), and the toe w...

Antitoxin production in antibiotic-associated colitis?

The production of antitoxin after Clostridium difficile-induced diarrhoea has not been reported previously. The stool of a patient with prolonged antibiotic-associated diarrhoea contained C. difficile toxin, and the serum neutralised the cytopathic effect of C. difficile toxin in tissue culture.

Experimental and Clinical Studies on Gramicidin.